Document Detail


Azathioprine in 50 rheumatoid arthritic patients intolerant or unresponsive to gold or penicillamine.
MedLine Citation:
PMID:  4064585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This is a retrospective review of 50 rheumatoid patients who had experienced side effects with gold and/or penicillamine and who were treated with azathioprine in routine clinical practice. The mean duration of the disease at commencement of azathioprine was 9.4 years; despite attempts to maintain the dose at 2.5 mg/kg.d because of minor side effects the average daily dose was 1.68 mg/kg.d. By one year, 11 (22%) had discontinued the drug due to side effects; 6 (12%) had not improved in any respect, 20 (40%) had a reduction in the total number of active joints with maintenance of function and in 13 (26%) the total number of active joints had been reduced by more than a half. During year 2 a further 4 discontinued therapy for adverse reactions. No further formal analysis has been performed though 31 patients were still on the drug with a mean duration of therapy for a period of 5 years. Ten of these had less than half their originally affected joints still active; this condition was usually associated with a fall in ESR and rise in haemoglobin but this was not invariable.
Authors:
E A Jenkins; B M Ansell; M A Hall; S P Liyanage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  4     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-01-08     Completed Date:  1986-01-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  278-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Arthritis, Rheumatoid / drug therapy*
Azathioprine / therapeutic use*
Blood Sedimentation
Female
Gold / therapeutic use*
Hemoglobins / analysis
Humans
Male
Middle Aged
Penicillamine / therapeutic use*
Retrospective Studies
Rheumatoid Factor / analysis
Chemical
Reg. No./Substance:
0/Hemoglobins; 446-86-6/Azathioprine; 52-67-5/Penicillamine; 7440-57-5/Gold; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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