Document Detail

Azathioprine hepatitis in kidney transplant recipients. A predisposing role of chronic viral hepatitis.
MedLine Citation:
PMID:  8685959     Owner:  NLM     Status:  MEDLINE    
Influence of viral liver diseases on the occurrence of azathioprine hepatitis was evaluated in 21 kidney transplant recipients. Diagnosis of azathioprine hepatitis was always based on jaundice, which disappeared after azathioprine withdrawal in 18 patients and after azathioprine dose reduction in 3 patients. Histopathological diagnosis of azathioprine toxicity was ascertained in 14 patients. Rechallenge with azathioprine performed in 4 patients, within 2-4 months after the first jaundice episode, resulted in relapse of jaundice in all cases. Viral hepatitis B virus and hepatitis C markers were present in all 20 tested patients (serum hepatitis B surface antigen in 6 patients and anti-HCV antibodies in 17 patients). Biopsy-proven chronic hepatitis was observed in 18 patients, including 14 chronic active hepatitis, 3 chronic persistent hepatitis and cirrhosis in 1. In kidney transplant recipients, azathioprine hepatitis seems to be facilitated or induced by hepatitis B virus or hepatitis C virus chronic hepatitis. Azathioprine reduction or withdrawal should therefore be combined with the diagnostic evaluation and the treatment of viral liver diseases.
S Pol; R Cavalcanti; F Carnot; C Legendre; F Driss; M L Chaix; E Thervet; N Chkoff; C Brechot; P Berthelot; H Kreis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  61     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-22     Completed Date:  1996-08-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1774-6     Citation Subset:  IM    
Services de Transplantation and Hépatologie, Hôpital Necker, Paris, France.
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MeSH Terms
Azathioprine / adverse effects*
Chronic Disease
Drug-Induced Liver Injury / etiology*
Enzyme-Linked Immunosorbent Assay
Hepatitis B Surface Antigens / blood
Hepatitis, Viral, Human / physiopathology*
Immunosuppressive Agents / adverse effects*
Kidney Transplantation / adverse effects*
Middle Aged
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Immunosuppressive Agents; 446-86-6/Azathioprine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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