| Azathiopine-steroid combination therapy for pulmonary arterial aneurysms in Behçet's disease. | |
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MedLine Citation:
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PMID: 11411965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasculitis is the primary pathological feature of Behçet's disease and in which pulmonary arterial aneurysm formations are rare but serious complications representing poor prognosis. There is no agreement on how to treat major venous and arterial disease. The use of steroids alone or corticosteroid treatment supplemented with cyclophosphamide or azathioprine is still controversial. We present three young male patients with Behçet's disease with aneurysms in the pulmonary arteries. In two of them, cyclophosphamide was the first choice of treatment, but this was ceased due to side effects. All three patients were then treated with azathioprine (2 mg/kg per day) and methylprednisolone (1.5 mg/kg per day). All three showed clinical improvement. Regression was observed radiologically in two (one minimal and the other complete). No complication related to therapy was encountered. Steroid therapy supplemented with azathioprine may be a good choice for treatment of pulmonary arterial aneurysms in Behçet's disease. |
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Authors:
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T Acican; O U Gürkan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Rheumatology international Volume: 20 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-06-19 Completed Date: 2001-11-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 171-4 Citation Subset: IM |
Affiliation:
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University of Ankara Medical Faculty, Department of Chest Disease, Mamak, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aneurysm / drug therapy*, etiology*, radiography Angiography Azathioprine / administration & dosage* Behcet Syndrome / complications*, diagnosis Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Follow-Up Studies Humans Male Methylprednisolone / administration & dosage* Middle Aged Pulmonary Artery* Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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446-86-6/Azathioprine; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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