Document Detail


Azathiopine-steroid combination therapy for pulmonary arterial aneurysms in Behçet's disease.
MedLine Citation:
PMID:  11411965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vasculitis is the primary pathological feature of Behçet's disease and in which pulmonary arterial aneurysm formations are rare but serious complications representing poor prognosis. There is no agreement on how to treat major venous and arterial disease. The use of steroids alone or corticosteroid treatment supplemented with cyclophosphamide or azathioprine is still controversial. We present three young male patients with Behçet's disease with aneurysms in the pulmonary arteries. In two of them, cyclophosphamide was the first choice of treatment, but this was ceased due to side effects. All three patients were then treated with azathioprine (2 mg/kg per day) and methylprednisolone (1.5 mg/kg per day). All three showed clinical improvement. Regression was observed radiologically in two (one minimal and the other complete). No complication related to therapy was encountered. Steroid therapy supplemented with azathioprine may be a good choice for treatment of pulmonary arterial aneurysms in Behçet's disease.
Authors:
T Acican; O U Gürkan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Rheumatology international     Volume:  20     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-19     Completed Date:  2001-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
Affiliation:
University of Ankara Medical Faculty, Department of Chest Disease, Mamak, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aneurysm / drug therapy*,  etiology*,  radiography
Angiography
Azathioprine / administration & dosage*
Behcet Syndrome / complications*,  diagnosis
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Follow-Up Studies
Humans
Male
Methylprednisolone / administration & dosage*
Middle Aged
Pulmonary Artery*
Tomography, X-Ray Computed
Treatment Outcome
Chemical
Reg. No./Substance:
446-86-6/Azathioprine; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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