Document Detail


Aza-retinoids as novel retinoid X receptor-specific agonists.
MedLine Citation:
PMID:  16364638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new structurally simple series of potent lipophilic aza-retinoids RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here demonstrate that the RXR activity profile is sensitive to the N-alkyl chain length. Further, we have expanded the work to include azadienoic acids, which exhibited many accessible conformations leading to a better understanding of the SAR around the series.
Authors:
Luc J Farmer; Kristen S Marron; Stacie S Canan Koch; C K Hwang; E Adam Kallel; Lin Zhi; Alex M Nadzan; Dave W Robertson; Youssef L Bennani
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Publication Detail:
Type:  Journal Article     Date:  2005-12-20
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  16     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  2352-6     Citation Subset:  IM    
Affiliation:
Ligand Pharmaceuticals Inc., 10255 Science Center Drive, San Diego, CA 92121, USA. luc_farmer@vrtx.com
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MeSH Terms
Descriptor/Qualifier:
Aza Compounds / chemical synthesis,  chemistry,  pharmacology*
Molecular Structure
Retinoid X Receptors / agonists*
Retinoids / chemical synthesis,  chemistry,  pharmacology*
Stereoisomerism
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Aza Compounds; 0/Retinoid X Receptors; 0/Retinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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