| Ay-4166 increases the sensitivity of insulin secretion to glucose in isolated perfused rat pancreas. | |
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MedLine Citation:
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PMID: 9543688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the effect of a therapeutic dose (3 microM) of AY-4166 on the glucose-stimulated insulin secretion, the rat pancreas was perfused with 5 to 15 mM glucose. AY-4166 did not affect the basal insulin secretion at 5 mM glucose, and increased the first and second phases of insulin secretion stimulated by 7.5 to 15 mM glucose. The dose-response curve of the insulin secretion to glucose was shifted to the left side by AY-4166. These results suggest that AY-4166 ist not a stimulator releasing insulin independently of glucose concentrations, but a potentiator of insulin secretion. |
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Authors:
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S Morimoto; O Mokuda; Y Sakamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 30 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-06-01 Completed Date: 1998-06-01 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 77-9 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Teikyo University School of Medicine, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclohexanes / pharmacology* Dose-Response Relationship, Drug Glucose / pharmacology* Hypoglycemic Agents / pharmacology Insulin / secretion* Male Pancreas / drug effects* Perfusion Phenylalanine / analogs & derivatives*, pharmacology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexanes; 0/Hypoglycemic Agents; 105816-04-4/nateglinide; 11061-68-0/Insulin; 50-99-7/Glucose; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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