Document Detail

Ay-4166 increases the sensitivity of insulin secretion to glucose in isolated perfused rat pancreas.
MedLine Citation:
PMID:  9543688     Owner:  NLM     Status:  MEDLINE    
To study the effect of a therapeutic dose (3 microM) of AY-4166 on the glucose-stimulated insulin secretion, the rat pancreas was perfused with 5 to 15 mM glucose. AY-4166 did not affect the basal insulin secretion at 5 mM glucose, and increased the first and second phases of insulin secretion stimulated by 7.5 to 15 mM glucose. The dose-response curve of the insulin secretion to glucose was shifted to the left side by AY-4166. These results suggest that AY-4166 ist not a stimulator releasing insulin independently of glucose concentrations, but a potentiator of insulin secretion.
S Morimoto; O Mokuda; Y Sakamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  30     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-01     Completed Date:  1998-06-01     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  77-9     Citation Subset:  IM    
Third Department of Internal Medicine, Teikyo University School of Medicine, Chiba, Japan.
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MeSH Terms
Cyclohexanes / pharmacology*
Dose-Response Relationship, Drug
Glucose / pharmacology*
Hypoglycemic Agents / pharmacology
Insulin / secretion*
Pancreas / drug effects*
Phenylalanine / analogs & derivatives*,  pharmacology
Rats, Wistar
Reg. No./Substance:
0/Cyclohexanes; 0/Hypoglycemic Agents; 105816-04-4/nateglinide; 11061-68-0/Insulin; 50-99-7/Glucose; 63-91-2/Phenylalanine

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