Document Detail


Axonal transport of gangliosides in the goldfish optic nerve.
MedLine Citation:
PMID:  5049309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Radioactive glucosamine and N-acetylmannosamine injected into the goldfish eye are incorporated into gangliosides that undergo rapid axonal transport to the optic nerve terminals. All ganglioside fractions are labeled. These data provide the first evidence that axonal transport has a role in neuronal ganglioside function and metabolism.
Authors:
D S Forman; R W Ledeen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  177     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1972 Aug 
Date Detail:
Created Date:  1972-09-29     Completed Date:  1972-09-29     Revised Date:  2011-12-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  630-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / metabolism*
Biological Transport
Carbon Isotopes
Chromatography, Thin Layer
Cyprinidae
Gangliosides / biosynthesis,  isolation & purification,  metabolism*
Glucosamine / metabolism
Hexosamines / metabolism
Mannose / metabolism
Optic Nerve / analysis,  metabolism*
Retina / metabolism
Tritium
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Gangliosides; 0/Hexosamines; 10028-17-8/Tritium; 31103-86-3/Mannose; 3416-24-8/Glucosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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