| Axonal transport of acetylcholinesterase in the diabetic mutant mouse. | |
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MedLine Citation:
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PMID: 6195008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the development of diabetic neuropathy in the mouse C57BL/Ks (db/db), the axonal transport of AChE molecular forms was tested in the sciatic nerve, by measuring the accumulation of enzyme activity in front of a nerve transection. No alteration of the fast flow rate of G4 and A12 molecular forms was found until 220 days of age. On the other hand, a reduced flow rate of G1 and G2 molecular forms, probably conveyed by slow axoplasmic flow, was noticed in the late phase of diabetic neuropathy. This result is consistent with the view that axonal dwindling could be related to disturbances of slow axonal transport and that the reduction in conduction velocity, observed at an earlier stage, may be due to other causes. |
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Authors:
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M Vitadello; J Y Couraud; R Hässig; A Gorio; L Di Giamberardino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental neurology Volume: 82 ISSN: 0014-4886 ISO Abbreviation: Exp. Neurol. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 143-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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metabolism* Animals Axonal Transport* Diabetes Mellitus / genetics, metabolism* Female Mice / metabolism* Mice, Inbred C57BL / genetics |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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