| Axonal tracing of the normal and regenerating visual pathway of mouse, rat, frog, and fish using manganese-enhanced MRI (MEMRI). | |
| | |
MedLine Citation:
|
PMID: 21769959 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To assess optic nerve (ON) regeneration after injury by applying manganese-enhanced MRI (MEMRI) in a study of comparative physiology between nonregenerating rat and mouse species and regenerating frog and fish species. MATERIALS AND METHODS: The normal visual projections of rats, mice, frogs, and fish was visualized by intravitreal MnCl(2) injection followed by MRI. Rats and mice with ON crush (ONC) were divided into nonregenerating (ONC only), and regenerating animals with peripheral nerve graft (ONC+PNG; rats) or lens injury (ONC+LI; mice) and monitored by MEMRI at 1 and 20 days post-lesion (dpl). Frog and fish with ON transection (ONT) were monitored by MEMRI up to 6 months postlesion (mpl). RESULTS: Signal intensity profiles of the Mn(2+) -enhanced ON were consistent with ON regeneration in the ONC+PNG and ONC+LI rat and mice groups, respectively, compared with the nonregenerating ONC groups. Furthermore, signal intensity profiles of the Mn(2+) -enhanced ON obtained between 1 mpl and 6 mpl in the fish and frog groups, respectively, were consistent with spontaneous, complete ON regeneration. CONCLUSION: Taken together, these results demonstrate that MEMRI is a viable method for serial, in vivo monitoring of normal, induced, and spontaneously regenerating optic nerve axons in different species. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. |
| | |
Authors:
|
Axel Sandvig; Ioanna Sandvig; Martin Berry; Oystein Olsen; Tina Bugge Pedersen; Christian Brekken; Marte Thuen |
Related Documents
:
|
8788279 - Lactate dehydrogenase activity and isoform distribution in the rat pelvic ganglion: eff... 9122359 - Influence of body size on lithium levels in rats. 3755369 - A comparison of regional somatostatin and neuropeptide y distribution in rat striatum a... 6850809 - Distribution of interchromatin granules in nuclear matrices obtained from nuclei exhibi... 1125329 - Distribution of silicon in the adult rat and rhesus monkey. 1611479 - Distribution of immunoreactive t-kininogen in rat nervous tissues. 11228169 - Intrauterine food restriction as a determinant of nephrosclerosis. 7277789 - Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme ... 11344579 - Stimulation of heme oxygenase in macrophages and liver by endotoxin. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-18 |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Laboratory of Regenerative Neurobiology, Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; Department of Neurosurgery, Umeå University Hospital, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elevated NRD1 metalloprotease expression plays a role in breast cancer growth and proliferation.
Next Document: Ultrashort echo time MRI of cortical bone at 7 tesla field strength: A feasibility study.