Document Detail


Axonal pathology of the skin in infantile neuroaxonal dystrophy.
MedLine Citation:
PMID:  3434228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrastructural studies on the skin of two patients affected by infantile neuroaxonal dystrophy (INAD) were performed to evaluate its diagnostic value and to discuss the etiology of INAD. While the majority of terminal axons around intradermal glands were dystophic consisting of tubulomembranous and tubulovesicular profiles sometimes accompanied by synaptic vesicles, there were only few dystophic axons inside intradermal nerve bundles. These observations suggest that the primary lesion of INAD is located in terminal and presynaptic axons. Therefore, terminal axons have to be investigated when a diagnostic skin biopsy is performed in INAD.
Authors:
S Kimura; Y Sasaki; I Warlo; H H Goebel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  75     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-03-04     Completed Date:  1988-03-04     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  212-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Axons / ultrastructure*
Child, Preschool
Female
Humans
Infant
Male
Nervous System Diseases / pathology*
Skin / innervation*
Sweat Glands / innervation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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