Document Detail


Axonal neuropathy and hearing loss associated with alpha interferon treatment in chronic hepatitis B: a case report.
MedLine Citation:
PMID:  15334319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of interferon alpha in chronic viral hepatitis and common side effects are well known, but axonal polyneuropathy and hearing loss have been rarely reported. A 58-year-old woman was administered interferon alpha-2a (9 MU/3 times a week) and lamividin (100 mg daily) with the diagnosis of chronic hepatitis B. At the fifth month of the treatment gait disturbance and tinnitus developed. In her neurological examination tandem gait was ataxic on the right side. Cerebral magnetic resonance imaging performed to elucidate a probable cerebral pathology revealed nonspecific millimetric hyperintense lesions thought to be related with her hypertension anamnesis. Electroneuromyography demonstrated mild axonal polyneuropathy. The finding of pure-tone audiometry was sensorineural hearing loss in her left ear. Our diagnosis was axonal polyneuropathy and sensorineural type hearing loss as a side effect of interferon. In conclusion, the development of polyneuropathy and sensorineural hearing loss in the same patient may suggest autoimmunity as the cause of these side effects.
Authors:
Ayşe Tunca; Mustafa Erbayrak; Sirin Aytaç; Cansel Türkay
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology     Volume:  15     ISSN:  1300-4948     ISO Abbreviation:  Turk J Gastroenterol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9515841     Medline TA:  Turk J Gastroenterol     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  97-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Medical School, Fatih University, Ankara, Turkey. etunca@e-kolay.net
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / adverse effects*
Autoimmune Diseases / chemically induced,  immunology
Autoimmunity / drug effects,  immunology
Axons
Female
Hearing Loss, Sensorineural / chemically induced*,  immunology
Hepatitis B, Chronic / drug therapy*
Humans
Interferon-alpha / adverse effects*
Middle Aged
Polyneuropathies / chemically induced*,  immunology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Interferon-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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