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Axonal loss of white matter in migraine without aura: A tract-based spatial statistics study.
MedLine Citation:
PMID:  23150889     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AimMultiple diffusion tensor imaging (DTI) derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of migraine patients without aura (MWoA).MethodsTwenty MWoA and 20 age-, education- and gender-matched healthy volunteers participated in this study. Tract-based spatial statistics (TBSS) was employed to investigate the WM abnormalities in MWoA by integrating multiple indices, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD).ResultsCompared with healthy controls, MWoA showed significantly lower FA, MD and AD in multiple brain regions, whereas no difference in RD was observed. Specifically, the overlap among the lower FA, MD, and AD was found in the genu, body, and splenium part of the corpus callosum (CC), the right anterior limb of the internal capsule (ALIC) and the posterior limb of the internal capsule (PLIC) in MWoA compared with healthy controls. Additionally, some of the above WM findings were significantly correlated with duration and headache frequency in MWoA.ConclusionGiven that decreased AD may suggest axonal loss, our findings may reveal axonal loss in MWoA.
Authors:
Dahua Yu; Kai Yuan; Wei Qin; Ling Zhao; Minghao Dong; Peng Liu; Xuejuan Yang; Jixin Liu; Jinbo Sun; Guangyu Zhou; Karen M von Deneen; Jie Tian
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  -     ISSN:  1468-2982     ISO Abbreviation:  Cephalalgia     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Life Sciences Research Center, Xidian University, People's Republic of China.
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