Document Detail

Axonal loss and cognitive deficits in term infants born small for gestational age with normal umbilical artery Doppler.
MedLine Citation:
PMID:  22740299     Owner:  NLM     Status:  Publisher    
Objective: Cognitive outcomes and structural changes in the central nervous system were assessed in children born at term small-for-gestational-age (SGA) who showed a normal umbilical artery (UA) Doppler. Outcomes were assessed when the children were 5-6.5 years of age. We used a novel approach to examine changes in neuronal integrity of the optic nerve. Methods: Two cohorts of infants born SGA (n = 40) and appropriate-for-gestational-age (AGA) weight (n = 39) were compared. Neuronal damage was evaluated using optical coherence tomography (OCT) of the optic nerve. Cognitive deficits were assessed with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Visuospatial perception was evaluated with the Rey-Osterreich Complex Figure (ROCF) tasks. Results: SGA infants showed significantly lower average retinal nerve fiber layer (RNFL) thickness (98.2 vs 104.5 µm; p = 0.012). The SGA group exhibited impaired performance in copy tasks on the ROCF (3.27 vs 3.56; p = 0.036), and a higher rate of suboptimal WPPSI Performance IQ, compared with AGA infants (15% vs 0%; p = 0.025). Conclusions: Term infants born SGA with normal UA Doppler are at increased risk for cognitive deficits and axonal loss in the RNFL at the age of 5-6.5 years. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Victoria Pueyo; Daniel Oros; Sofía Valle; Helena Tuquet; Noemí Güerri; Marta Argüelles; Purificación Ventura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza Spain; Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain.
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