| Axonal damage in multiple sclerosis. | |
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MedLine Citation:
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PMID: 21425267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple sclerosis is a debilitating disease of the central nervous system that has been characteristically classified as an immune-mediated destruction of myelin, the protective coating on nerve fibers. Although the mechanisms responsible for the immune attack to central nervous system myelin have been the subject of intense investigation, more recent studies have focused on the neurodegenerative component, which is cause of clinical disability in young adults and appears to be only partially controlled by immunomodulatory therapies. Here, we review distinct, but not mutually exclusive, mechanisms of pathogenesis of axonal damage in multiple sclerosis patients that are either consequent to long-term demyelination or independent from it. We propose that the complexity of axonal degeneration and the heterogeneity of the underlying pathogenetic mechanisms should be taken into consideration for the design of targeted therapeutic intervention. |
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Authors:
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Jeffery D Haines; Matilde Inglese; Patrizia Casaccia |
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Publication Detail:
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Type: Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Mount Sinai journal of medicine, New York Volume: 78 ISSN: 1931-7581 ISO Abbreviation: Mt. Sinai J. Med. Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-07-27 Revised Date: 2012-05-22 |
Medline Journal Info:
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Nlm Unique ID: 0241032 Medline TA: Mt Sinai J Med Country: United States |
Other Details:
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Languages: eng Pagination: 231-43 Citation Subset: IM |
Copyright Information:
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© 2011 Mount Sinai School of Medicine. |
Affiliation:
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Departments of Neuroscience Neurology and Genetics and Genomics, Mount Sinai School of Medicine, New York, NY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Adult Animals Aspartic Acid / analogs & derivatives, metabolism Axons* / metabolism, pathology Humans Immunity / drug effects Immunologic Factors* / metabolism, therapeutic use Inflammation / immunology, physiopathology Multiple Sclerosis* / metabolism, pathology, physiopathology, therapy Myelin Sheath* / metabolism, pathology Nerve Degeneration* / metabolism, pathology Nervous System Autoimmune Disease, Experimental / metabolism, pathology, physiopathology, therapy Positron-Emission Tomography |
| Grant Support | |
ID/Acronym/Agency:
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NS42925-08/NS/NINDS NIH HHS; R01 NS042925/NS/NINDS NIH HHS; R01 NS042925-07S1/NS/NINDS NIH HHS; R01 NS042925-08/NS/NINDS NIH HHS; R01 NS042925-09/NS/NINDS NIH HHS; R01-NS42925-07S1/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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