Document Detail

Axonal atrophy in the painful peripheral neuropathy in AIDS.
MedLine Citation:
PMID:  1964527     Owner:  NLM     Status:  MEDLINE    
We compared the sural nerves from patients with AIDS; four with the painful peripheral neuropathy (PPN), three patients with non-painful distal symmetrical peripheral neuropathy (DSPN), one without clinical peripheral nerve involvement and two human immunodeficiency virus negative controls. Fibre diameter distributions showed a slight reduction in larger fibres in all patients with AIDS compared with controls. No significant difference was found in the relative frequency distribution of the lamellae counts between any of the groups. The relative frequency distribution of axonal area of myelinated fibres did not differ between controls, non-painful DSPN or the patient without peripheral nerve involvement; however, all patients with PPN showed marked reduction in the number of axons of myelinated fibres of larger area which was significant when compared to each patient from the other groups (P less than 0.0001). This indicates that the reduction in larger fibres in PPN is mostly due to axonal atrophy rather than selective fibre loss. Axonal atrophy is associated with painful peripheral neuropathy in AIDS but not with those without pain. The possible role of axonal atrophy as a pathological substrate for pain is discussed.
G N Fuller; J M Jacobs; R J Guiloff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neuropathologica     Volume:  81     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-06     Completed Date:  1991-05-06     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  IM; X    
Department of Neuropathology, Institute of Neurology, London, Great Britain.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*,  pathology
Atrophy / pathology
Axons / pathology*
Microscopy, Electron
Pain / etiology,  pathology*
Peripheral Nervous System Diseases / etiology,  pathology*
Sural Nerve / pathology

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