| Axonal Injury in Young Pediatric Head Trauma: A Comparison Study of β-amyloid Precursor Protein (β-APP) Immunohistochemical Staining in Traumatic and Nontraumatic Deaths* | |
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MedLine Citation:
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PMID: 21595698 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We tested the independent utility of β-amyloid precursor protein (β-APP) immunohistochemical staining as evidence of brain trauma in the deaths of young children. Blinded reviewers retrospectively reviewed immunostained brain tissues from homicidal deaths, age-matched control cases without evidence of trauma, as well as cases of sudden infant death syndrome (SIDS). The reviewers correctly identified five of the seven cases with documented inflicted head trauma. However, one of seven age-matched control cases and one of 10 SIDS/sudden unexplained death in infancy (SUDI) cases demonstrated staining patterns similar to those seen in cases of inflicted trauma. We discuss these cases and the circumstances surrounding them with the intent to explain the difficulties associated with immunohistological interpretation of axonal injury. Although the utility of β-APP is quite powerful if not confounded by global hypoxic-ischemic injury, ultimately, β-APP studies should be only one piece of information in the determination of cause and manner of death. |
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Authors:
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Michael W Johnson; Lisa Stoll; Ana Rubio; Juan Troncoso; Olga Pletnikova; David R Fowler; Ling Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-19 |
Journal Detail:
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Title: Journal of forensic sciences Volume: - ISSN: 1556-4029 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375370 Medline TA: J Forensic Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 American Academy of Forensic Sciences. |
Affiliation:
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Office of the Chief Medical Examiner (OCME), Urban County Government Center, Louisville, KY. Office of the Chief Medical Examiner, State of Maryland, Baltimore, MD. Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD. Departments of Pathology and Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD. Department of Pediatrics, University of Maryland, Baltimore, MD. Key Laboratory of Evidence Science, China University of Political Science and Law, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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