Document Detail


Axonal injury in young pediatric head trauma: a comparison study of β-amyloid precursor protein (β-APP) immunohistochemical staining in traumatic and nontraumatic deaths.
MedLine Citation:
PMID:  21595698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the independent utility of β-amyloid precursor protein (β-APP) immunohistochemical staining as evidence of brain trauma in the deaths of young children. Blinded reviewers retrospectively reviewed immunostained brain tissues from homicidal deaths, age-matched control cases without evidence of trauma, as well as cases of sudden infant death syndrome (SIDS). The reviewers correctly identified five of the seven cases with documented inflicted head trauma. However, one of seven age-matched control cases and one of 10 SIDS/sudden unexplained death in infancy (SUDI) cases demonstrated staining patterns similar to those seen in cases of inflicted trauma. We discuss these cases and the circumstances surrounding them with the intent to explain the difficulties associated with immunohistological interpretation of axonal injury. Although the utility of β-APP is quite powerful if not confounded by global hypoxic-ischemic injury, ultimately, β-APP studies should be only one piece of information in the determination of cause and manner of death.
Authors:
Michael W Johnson; Lisa Stoll; Ana Rubio; Juan Troncoso; Olga Pletnikova; David R Fowler; Ling Li
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Publication Detail:
Type:  Journal Article     Date:  2011-05-19
Journal Detail:
Title:  Journal of forensic sciences     Volume:  56     ISSN:  1556-4029     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2012-04-05     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1198-205     Citation Subset:  IM    
Copyright Information:
© 2011 American Academy of Forensic Sciences.
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein Precursor / metabolism*
Axons / metabolism*,  pathology
Brain / metabolism*,  pathology*
Cardiopulmonary Resuscitation
Case-Control Studies
Child, Preschool
Coroners and Medical Examiners
Craniocerebral Trauma / metabolism*
Cytoplasm / metabolism,  pathology
Female
Forensic Pathology
Humans
Immunohistochemistry
Infant
Infant, Newborn
Male
Neurons / metabolism,  pathology
Retrospective Studies
Staining and Labeling
Sudden Infant Death / pathology
Grant Support
ID/Acronym/Agency:
P01 AG004953/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein Precursor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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