Document Detail

Axon specification in hippocampal neurons.
MedLine Citation:
PMID:  12135774     Owner:  NLM     Status:  MEDLINE    
Neurons are the most highly polarized cells, comprised of two structurally and functionally distinct parts, axons and dendrites. This asymmetry enables a vectorial flow of signaling within neurons. One of the most fundamental questions still to be answered in neuroscience is how these two specialized processes initially develop. The first manifestation of polarization occurs when one of the immature neurites acquires axonal characteristics. We review recent advances that have highlighted the involvement of several cellular events in the initial formation of the axon, including membrane traffic and cytoskeletal rearrangement. We then discuss the molecular mechanisms underlying axon formation, focusing on the Rho family small GTPases and an axon-inducing neuronal protein, CRMP-2.
Yuko Fukata; Toshihide Kimura; Kozo Kaibuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neuroscience research     Volume:  43     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-23     Completed Date:  2002-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  305-15     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ireland Ltd. and the Japan Neuroscience Society.
Department of Cell Pharmacology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.
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MeSH Terms
Axons / physiology*
Cell Polarity
Cells, Cultured
Hippocampus / physiology*
Intercellular Signaling Peptides and Proteins
Nerve Tissue Proteins / physiology
Neurons / metabolism,  physiology*
rho GTP-Binding Proteins / physiology
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Nerve Tissue Proteins; 0/collapsin response mediator protein-2; EC GTP-Binding Proteins

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