| Axon-regenerating retinal ganglion cells in adult rats synthesize the cell adhesion molecule L1 but not TAG-1 or SC-1. | |
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MedLine Citation:
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PMID: 9245496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retinal ganglion cells (RGCs) in rats regenerate axons in the presence of a PNS nerve graft. To determine if axon-regenerating RGCs synthesize cell adhesion/recognition molecules which they possessed during development, retinae were subjected to in situ hybridization with antisense cRNA probes of L1, TAG-1, and SC-1 (and GAP-43 for comparison). L1 and TAG-1 (and GAP-43) proteins on axons were detected with antibodies. L1, TAG-1, and SC-1 (and Gap-43) mRNAs and L1 and TAG-1 (and Gap-43) proteins were expressed by RGCs in embryonic, postnatal, and adult rats. After optic nerve lesion (ONL), the surviving RGCs between 2 and 28 days after ONL continued to express L1. TAG-1 and SC-1 expression, however is lost. In grafted rats, axon-regenerating RGCs express L1 (together with GAP-43) but neither TAG-1 nor SC-1. Thus, axonal regeneration in grafted rats occurs in the presence of L1 (and GAP-43) but in the absence of TAG-1 and SC-1). |
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Authors:
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M Jung; B Petrausch; C A Stuermer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 9 ISSN: 1044-7431 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-18 Completed Date: 1997-09-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 116-31 Citation Subset: IM |
Affiliation:
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Faculty of Biology, University of Konstanz, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activated-Leukocyte Cell Adhesion Molecule Aging / metabolism Animals Animals, Newborn / growth & development, metabolism Axons / physiology* Cell Adhesion Molecules, Neuronal* Embryo, Mammalian / metabolism Extracellular Matrix Proteins / biosynthesis Female Immunologic Techniques In Situ Hybridization Leukocyte L1 Antigen Complex Membrane Glycoproteins / biosynthesis Nerve Regeneration* Nerve Tissue Proteins / biosynthesis Neural Cell Adhesion Molecules / biosynthesis* Optic Nerve / pathology Rats Rats, Wistar Retinal Ganglion Cells / metabolism*, physiology* Sciatic Nerve / transplantation |
| Chemical | |
Reg. No./Substance:
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0/Activated-Leukocyte Cell Adhesion Molecule; 0/Cell Adhesion Molecules, Neuronal; 0/Extracellular Matrix Proteins; 0/Leukocyte L1 Antigen Complex; 0/Membrane Glycoproteins; 0/Nerve Tissue Proteins; 0/Neural Cell Adhesion Molecules; 0/contactin 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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