Document Detail


Axillary recurrence in women with a negative sentinel lymph node and no axillary dissection in breast cancer.
MedLine Citation:
PMID:  16425295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Sentinel lymph node biopsy (SLNB) is widely used for staging breast cancer. SLNB accurately determines axillary lymph node status with a low false negative rate. There remains concern that omitting axillary dissection may lead to recurrence in the axilla, and impact long term survival. The purpose of this study was to determine the frequency of axillary lymph node recurrence in patients who had a negative sentinel lymph node and did not undergo axillary node dissection. METHODS: Data was collected on all patients who had negative SLNB at Roswell Park Cancer Institute between July 1997 and June 2002. Demographics, type of operation, postoperative systemic, and radiation therapy, co-morbidity score, hormone receptor status, and the pathologic features of the tumor were abstracted for each patient. For each woman with recurrence, the dates of recurrence, the site(s) of recurrence, and the treatment for recurrence were recorded. RESULTS: With a median follow-up of 33 months, 15 of 335 (4.5%) women who had negative SLNBs and who did not undergo completion axillary dissection developed a cancer recurrence. Only two patients (0.6%) had an axillary recurrence. CONCLUSIONS: The rate of axillary recurrence following a negative sentinel node biopsy is the same or less than axillary lymph node dissection (ALND) alone. Concerns that omitting completion axillary dissection following a negative SLNB will increase the rate of axillary recurrence appear unfounded.
Authors:
J Alexander Palesty; Jason M Foster; Thelma C Hurd; Nancy Watroba; Hamed Rezaishiraz; Stephen B Edge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  93     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-25     Completed Date:  2006-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Affiliation:
Department of Breast and Soft Tissue Surgery, Roswell Park Cancer Institute, Department of Surgery, State University of New York at Buffalo, New York 14263-0001, USA. apalesty@stmh.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Axilla
Bone Neoplasms / secondary
Breast Neoplasms / pathology*,  radiotherapy,  surgery
Combined Modality Therapy
Data Collection
Female
Humans
Lymph Node Excision
Lymph Nodes / pathology*
Lymphatic Metastasis
Mastectomy / statistics & numerical data
Mastectomy, Segmental / statistics & numerical data
Middle Aged
Neoplasm Recurrence, Local / epidemiology*
Neoplasm Staging
Predictive Value of Tests
Prognosis
Sentinel Lymph Node Biopsy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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