Document Detail


Axial specification for sensory organs versus non-sensory structures of the chicken inner ear.
MedLine Citation:
PMID:  9389659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A mature inner ear is a complex labyrinth containing multiple sensory organs and nonsensory structures in a fixed configuration. Any perturbation in the structure of the labyrinth will undoubtedly lead to functional deficits. Therefore, it is important to understand molecularly how and when the position of each inner ear component is determined during development. To address this issue, each axis of the otocyst (embryonic day 2.5, E2.5, stage 16-17) was changed systematically at an age when axial information of the inner ear is predicted to be fixed based on gene expression patterns. Transplanted inner ears were analyzed at E4.5 for gene expression of BMP4 (bone morphogenetic protein), SOHo-1 (sensory organ homeobox-1), Otx1 (cognate of Drosophila orthodenticle gene), p75NGFR (nerve growth factor receptor) and Msx1 (muscle segment homeobox), or at E9 for their gross anatomy and sensory organ formation. Our results showed that axial specification in the chick inner ear occurs later than expected and patterning of sensory organs in the inner ear was first specified along the anterior/posterior (A/P) axis, followed by the dorsal/ventral (D/V) axis. Whereas the A/P axis of the sensory organs was fixed at the time of transplantation, the A/P axis for most non-sensory structures was not and was able to be re-specified according to the new axial information from the host. The D/V axis for the inner ear was not fixed at the time of transplantation. The asynchronous specification of the A/P and D/V axes of the chick inner ear suggests that sensory organ formation is a multi-step phenomenon, rather than a single inductive event.
Authors:
D K Wu; F D Nunes; D Choo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  125     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-12     Completed Date:  1998-02-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM; S    
Affiliation:
National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA. dwu@pop.nidcd.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Avian Proteins*
Body Patterning*
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins / genetics
Cell Differentiation
Chick Embryo
Cochlear Duct / embryology
Ear, Inner / embryology*,  transplantation
Gene Expression Regulation, Developmental*
Hair Cells, Auditory / cytology
Homeodomain Proteins / genetics
Immunohistochemistry
In Situ Hybridization
MSX1 Transcription Factor
Nerve Tissue Proteins / genetics
Otx Transcription Factors
Phenotype
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor / genetics
Saccule and Utricle / embryology
Semicircular Canals / embryology
Transcription Factors*
Transplantation
Chemical
Reg. No./Substance:
0/Avian Proteins; 0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/Homeodomain Proteins; 0/MSX1 Transcription Factor; 0/Nerve Tissue Proteins; 0/Otx Transcription Factors; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 0/SOHO-1 protein, Gallus gallus; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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