Document Detail

Axial interactions during neurogenesis in dysraphic mice.
MedLine Citation:
PMID:  2694866     Owner:  NLM     Status:  MEDLINE    
The spatial relationships of midline axial structures were compared in normal and dysraphic embryos of the loop-tail (Lp) mutant mouse at 9 days of gestation, and the distribution of two glycoproteins, fibronectin and laminin, was determined in this region by means of immunofluorescence histochemistry. At various levels of the trunk in abnormal embryos, the notochord, ventral midline of the neural folds, dorsal aorta(e) and/or gut were variably separated from one another, in contrast to the closer contact that occurred among these midaxial structures at comparable trunk levels in normal embryos. Positive anti-fibronectin and anti-laminin reactions were noted within areas of contact in the normal embryos and at the interfaces of tissue separation in the abnormal embryos. Although the intensity of the immunofluorescent reaction could not be assessed or compared quantitatively, the presence and distribution of fibronectin and laminin in the abnormal embryos suggest that these two glycoproteins may not be causally or fundamentally involved in producing the abnormal spatial relationships and separation of the midaxial structures.
D B Wilson; D P Wyatt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anatomy and embryology     Volume:  180     ISSN:  0340-2061     ISO Abbreviation:  Anat. Embryol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-01     Completed Date:  1990-03-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7505194     Medline TA:  Anat Embryol (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  515-9     Citation Subset:  IM    
Division of Anatomy, School of Medicine, University of California, San Diego, La Jolla 92093.
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MeSH Terms
Fibronectins / metabolism*
Fluorescent Antibody Technique
Laminin / metabolism*
Mice, Mutant Strains / embryology*
Microscopy, Fluorescence
Spine / embryology,  innervation*
Grant Support
Reg. No./Substance:
0/Fibronectins; 0/Laminin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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