Document Detail


Awareness of the functioning of one's own limbs mediated by the insular cortex?
MedLine Citation:
PMID:  16079395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Normally, we are aware of the current functions of our arms and legs. However, this self-evident status may change dramatically after brain damage. Some patients with "anosognosia" typically are convinced that their limbs function normally, although they have obvious motor defects after stroke. Such patients may experience their own paretic limbs as strange or as not belonging to them and may even attribute ownership to another person and try to push their paralyzed limb out of bed. These odd beliefs have been attributed to disturbances somewhere in the right hemisphere. Here, we use lesion mapping in 27 stroke patients to show that the right posterior insula is commonly damaged in patients with anosognosia for hemiplegia/hemiparesis but is significantly less involved in hemiplegic/hemiparetic patients without anosognosia. The function of the posterior insular cortex has been controversially discussed. Recent neuroimaging results in healthy subjects revealed specific involvement of this area in the subject's feeling of being versus not being involved in a movement. Our finding corresponds with this observation and suggests that the insular cortex is integral to self-awareness and to one's beliefs about the functioning of body parts.
Authors:
Hans-Otto Karnath; Bernhard Baier; Thomas Nägele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  25     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-04     Completed Date:  2006-02-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7134-8     Citation Subset:  IM    
Affiliation:
Department of Cognitive Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany. Karnath@uni-tuebingen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Awareness*
Cerebral Cortex / pathology,  physiopathology*,  radiography
Extremities / physiopathology*
Female
Hemiplegia / etiology,  physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Perceptual Disorders / diagnosis,  etiology*,  psychology
Stroke / complications,  diagnosis,  physiopathology*,  psychology*
Tomography, Spiral Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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