Document Detail

Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombe.
MedLine Citation:
PMID:  20388511     Owner:  NLM     Status:  MEDLINE    
We identified SPBC1685.07c of Schizosaccharomyces pombe as a novel vacuolar protein, Avt5p, with similarity to vacuolar amino acid transporters Avt5p from Saccharomyces cerevisiae. Avt5p localizes to the vacuolar membrane and upon disruption of avt5, uptake of histidine, glutamate, tyrosine, arginine, lysine or serine was impaired. During nitrogen starvation, the transient increase of vacuolar lysine transport observed for wild-type cells still occurred in the mutant cells, however, uptake of glutamate did not significantly increase in response to nitrogen starvation. Our results show that under diverse growth conditions Avt5p is involved in vacuolar transport of a selective set of amino acids.
Soracom Chardwiriyapreecha; Hiroyuki Mukaiyama; Takayuki Sekito; Tomoko Iwaki; Kaoru Takegawa; Yoshimi Kakinuma
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-11
Journal Detail:
Title:  FEBS letters     Volume:  584     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2339-45     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Department of Applied Bioresource Science, Faculty of Agriculture, Ehime University, Ehime, Japan.
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MeSH Terms
Amino Acid Transport Systems / genetics,  metabolism*
Amino Acids / metabolism*
Arginine / metabolism
Biological Transport / genetics
Glutamic Acid / metabolism
Histidine / metabolism
Lysine / metabolism
Membrane Proteins / genetics,  metabolism*
Schizosaccharomyces / genetics,  metabolism*
Schizosaccharomyces pombe Proteins / metabolism
Tyrosine / metabolism
Vacuoles / metabolism*
Vesicular Transport Proteins / metabolism
Reg. No./Substance:
0/Amino Acid Transport Systems; 0/Amino Acids; 0/Avt5 protein, S pombe; 0/Membrane Proteins; 0/Schizosaccharomyces pombe Proteins; 0/Vesicular Transport Proteins; 55520-40-6/Tyrosine; 56-86-0/Glutamic Acid; 56-87-1/Lysine; 71-00-1/Histidine; 74-79-3/Arginine

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