Document Detail

Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and pig farms.
MedLine Citation:
PMID:  9234429     Owner:  NLM     Status:  MEDLINE    
We determined the association between the use of the glycopeptide antibiotic avoparcin as a growth promoter and the occurrence of Enterococcus faecium (VREF) with high-level resistance to vancomycin (MIC > or = 64 micrograms ml-1) on poultry and pig farms. The investigations were conducted as retrospective cohort studies, where groups of farms exposed or not exposed to avoparcin between September 1994 and April 1995 were compared. In poultry, the association between the use of avoparcin and the occurrence of VREF was confounded by the use of broad-spectrum antibiotics, and the adjusted relative risk was 2.9 (1.4-5.9). In pigs, the association had a similar magnitude with a non-adjusted relative risk of 3.3 (0.9-12.3). The similar findings in the two studies provide evidence in favour of a causal association between the use of avoparcin and the occurrence of VREF on farms, and suggest that food animals constitute a potential reservoir of infection for VREF in humans.
F Bager; M Madsen; J Christensen; F M Aarestrup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Preventive veterinary medicine     Volume:  31     ISSN:  0167-5877     ISO Abbreviation:  Prev. Vet. Med.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-03     Completed Date:  1997-09-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8217463     Medline TA:  Prev Vet Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  95-112     Citation Subset:  IM    
Danish Veterinary Laboratory, Copenhagen, Denmark.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*,  therapeutic use
Antibodies, Bacterial / analysis
Cohort Studies
Denmark / epidemiology
Disease Susceptibility
Drug Resistance, Microbial
Enterococcus faecium / drug effects*,  immunology
Gram-Positive Bacterial Infections / drug therapy,  epidemiology,  veterinary*
Growth Substances / pharmacology*,  therapeutic use
Poultry Diseases / drug therapy,  epidemiology,  microbiology
Retrospective Studies
Specific Pathogen-Free Organisms
Swine Diseases / drug therapy,  epidemiology,  microbiology
Vancomycin / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antibodies, Bacterial; 0/Glycopeptides; 0/Growth Substances; 1404-90-6/Vancomycin; 37332-99-3/avoparcin

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