| Avoiding and managing bleeding complications in patients with non-ST-segment elevation acute coronary syndromes. | |
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MedLine Citation:
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PMID: 18508853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antithrombotic therapy coupled with early use of cardiac catheterization and revascularization have decreased morbidity and mortality rates in patients who have acute ischemic heart disease but who carry a risk for bleeding. Bleeding complications in patients with acute coronary syndromes are associated with worse clinical outcomes, including recurrent ischemic events and death. Determining the appropriate balance between preventing ischemic events and causing bleeding in patients with acute coronary syndromes present a challenging problem for clinicians. Antithrombotics studied in recent clinical trials that have focused on bleeding reduction include bivalirudin and fondaparinux. In this review, the incidence, predictors, and clinical outcomes associated with bleeding are discussed. Furthermore, the association between antithrombotic agents and bleeding and propose strategies to prevent bleeding complications are also discussed. |
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Authors:
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Thomas Z Potsis; Christos Katsouras; John A Goudevenos |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-05-28 |
Journal Detail:
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Title: Angiology Volume: 60 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2009 Apr-May |
Date Detail:
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Created Date: 2009-04-20 Completed Date: 2009-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 148-58 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medical School, University of Ioannina, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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physiopathology,
therapy* Anticoagulants / therapeutic use* Electrocardiography* Factor X / antagonists & inhibitors Fibrinolytic Agents / adverse effects, therapeutic use* Heart Catheterization / adverse effects, methods* Hemorrhage / drug therapy, etiology, prevention & control* Humans Myocardial Revascularization / adverse effects, methods* Polysaccharides / therapeutic use Prognosis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Fibrinolytic Agents; 0/Polysaccharides; 0/fondaparinux; 9001-29-0/Factor X |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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