Document Detail


Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation.
MedLine Citation:
PMID:  22836139     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To evaluate whether extracorporeal carbon dioxide removal by means of a pumpless extracorporeal lung-assist (PECLA) device could be an effective and safe alternative to invasive mechanical ventilation in patients with chronic pulmonary disease and acute hypercapnic ventilatory failure not responding to noninvasive ventilation (NIV). METHODS: In this multicentre, retrospective study, 21 PECLA patients were compared with respect to survival and procedural outcomes to 21 matched controls with conventional invasive mechanical ventilation. Matching criteria were underlying diagnosis, age, Simplified Acute Physiology Score II and pH at ICU admission. RESULTS: Of the 21 patients treated with PECLA, 19 (90 %) did not require intubation. Median PaCO(2) levels and pH in arterial blood prior to PECLA were 84.0 mmHg (54.2-131.0) and 7.28 (7.10-7.41), respectively. Within 24 h, median PaCO(2) levels and pH had significantly improved to 52.1 (33.0-70.1; p < 0.001) and 7.44 (7.27-7.56; p < 0.001), respectively. Two major and seven minor bleeding complications related to the device occurred. Further complications were one pseudoaneurysm and one heparin-induced thrombocytopenia type 2. Compared to the matched control group, there was a trend toward a shorter hospital length of stay in the PECLA group (adjusted p = 0.056). There was no group difference in the 28-day (24 % vs. 19 %, adjusted p = 0.845) or 6-month mortality (33 % vs. 33 %). CONCLUSIONS: In this study the use of extracorporeal carbon dioxide removal allowed avoiding intubation and invasive mechanical ventilation in the majority of patients with acute on chronic respiratory failure not responding to NIV. Compared to conventional invasive ventilation, short- and long-term survivals were similar.
Authors:
Stefan Kluge; Stephan A Braune; Markus Engel; Axel Nierhaus; Daniel Frings; Henning Ebelt; Alexander Uhrig; Maria Metschke; Karl Wegscheider; Norbert Suttorp; Simone Rousseau
Related Documents :
21551479 - Beneficial effect of pioglitazone on the outcome of catheter ablation in patients with ...
1358129 - Clinical aspects and distribution of immunologically active cells in the nasal mucosa o...
19082719 - A randomized prospective trial comparing unsedated endoscopy via transnasal and transor...
6708699 - Cryotherapy for chronic vasomotor rhinitis: technique and patient selection for improve...
21309939 - Effectiveness of epidural analgesia following open liver resection.
21457429 - Single-incision sling system as primary treatment of female stress urinary incontinence...
6845999 - Amputation for tumor of the upper arm.
21207449 - A novel method for internal nasal valve reconstruction: h-graft technique.
9771409 - Transcatheter coil embolotherapy: a safe and effective option for major colonic haemorr...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-27
Journal Detail:
Title:  Intensive care medicine     Volume:  -     ISSN:  1432-1238     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany, skluge@uke.uni-hamburg.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Outcome and complications after dual mobility total hip replacement: fifty cases with a minimum of s...
Next Document:  Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric ox...