| Avoiding hypothermia, an intervention to prevent morbidity and mortality from pneumonia in young children. | |
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MedLine Citation:
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PMID: 20135749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Observations and experiments in animals and human beings grant plausibility to the hypothesis that hypothermia is a risk factor for pneumonia. Exposure of body to cold stress causes alterations in the systemic and local defenses against respiratory infections, favoring the infection by inhalation of pathogens normally present in the oropharynx. Neonates and young infants with hypothermia have an increased risk of death; however, there is no strong demonstration that hypothermia leads to pneumonia in these children. Studies that properly addressed the problem of confounding variables have shown an association between cold weather and pneumonia incidence. Probably the strongest evidence that supports the plausibility of the hypothesis is provided by the controlled comparison between patients with traumatic brain injury treated with hypothermia and those treated under normal body temperature. The association between exposure to cold and pneumonia is strong enough to warrant further research focused in young children in developing countries. |
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Authors:
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Antonio Pio; Betty R Kirkwood; Sandy Gove |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 29 ISSN: 1532-0987 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: United States |
Other Details:
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Languages: eng Pagination: 153-9 Citation Subset: IM |
Affiliation:
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Public Health and Respiratory Diseases, Mar del Plata, Argentina. antonio_pio_md@yahoo.com.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Child, Preschool Humans Hypothermia / complications*, prevention & control* Infant Intervention Studies Pneumonia / complications*, mortality |
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