Document Detail

Avoidance performance, cue and response-choice discrimination after neuroleptic treatment.
MedLine Citation:
PMID:  7163355     Owner:  NLM     Status:  MEDLINE    
The effects of pimozide on discriminated avoidance performance in a Y-maze were evaluated in mice. Relatively low doses of pimozide (0.4 mg/kg) retarded acquisition of an active avoidance response. The avoidance deficit induced by this dosage was largely eliminated among mice that had received either 1 or 2 previous avoidance training sessions, but was still evident in mice treated with a higher drug dosage (0.8 mg/kg). If mice were initially trained in the drug condition, the disruptive effects were still evident in a later test conducted in the absence of the drug treatment. In contrast to the avoidance deficits, pimozide did not disrupt the acquisition or the performance of a cue- or response-choice discrimination. That is, once a running response was initiated (on avoidance trials) pimozide treated animals appeared capable of appropriately directing the response. It is suggested that at the dosages used pimozide did not affect S-S learning or learning response-outcome contingencies, but rather hindered performance owing to deficits in response initiation processes. Moreover, within a task involving aversive motivation pimozide did not appear to reduce the reinforcement derived for correct responding.
H Anisman; A Corradini; T N Tombaugh; R M Zacharko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  17     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-04-21     Completed Date:  1983-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1245-9     Citation Subset:  IM    
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MeSH Terms
Association Learning / drug effects
Avoidance Learning / drug effects*
Choice Behavior / drug effects*
Discrimination Learning / drug effects*
Dose-Response Relationship, Drug
Pimozide / pharmacology*
Reg. No./Substance:

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