Document Detail

Avoidance of anencephalic and spina bifida births by maternal serum-alphafetoprotein screening.
MedLine Citation:
PMID:  78097     Owner:  NLM     Status:  MEDLINE    
Screening of 11 585 pregnant women between 16 and 20 completed weeks' gestation for raised serum-alphafetoprotein (A.F.P.) levels showed that the birth of 81.4% of babies with open neural-tube defects could be avoided. The screening test was sensitive enough to detect 93% of those affected and serum-A.F.P. levels above the point at which intervention shouldbe considered were found in 1.7% of pregnancies. After 75.2% of false-positives had been excluded by ultrasonography or by a repeat of the serum test, only 0.63% of pregnancies proceeded to amniocentesis, 46.6% of amniocenteses showed raised amniotic A.F.P. levels due to fetal abnormality. Fetal loss by abortion or perinatal death after amniocentesis occurred in 0.034% of pregnancies screeded, 75% being associated with threatened abortion before amniocentesis. There were no terminations of normal pregnancies due to false-positive amniotic A.F.P. results. It is concluded that voluntary maternal serum-A.F.P. screening has a valuable role in antenatal care.
M A Ferguson-Smith; H A Rawlinson; H M May; H A Tait; J D Vince; A A Gibson; H P Robinson; J G Ratcliffe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-08-28     Completed Date:  1978-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1330-3     Citation Subset:  AIM; IM    
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MeSH Terms
Anencephaly / blood,  diagnosis*,  epidemiology
Evaluation Studies as Topic
Pregnancy Trimester, Second
Regional Medical Programs
Spina Bifida Occulta / blood,  diagnosis*,  epidemiology
alpha-Fetoproteins / analysis*
Reg. No./Substance:

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