Document Detail

Avian digestive tract simulation to study the effect of grit geochemistry and food on Pb shot bioaccessibility.
MedLine Citation:
PMID:  20000544     Owner:  NLM     Status:  MEDLINE    
Lead shot dissolution was investigated in a dynamic in vitro simulated avian gizzard-intestine system. The method allows simulated digestive fluid to pass (at intervals) from a gizzardlike environment to an intestine-based one, and then considers the dissolution of Pb shot (0-3 pellets) in the presence of differing grit geochemistries (siliceous and calcareous) and variable amounts of food (0-4 g of partially milled wheat seed). Dissolved Pb levels in simulated gizzards were consistently higher in the presence of siliceous, than with calcareous, grit. This was also seen in simulated intestines, except when less food was used (0-1 g), when Pb levels in solution were higher in calcareous systems. The Pb concentrations in gizzard and intestine solutions increased directly with the number of Pb shot used. In all treatments Pb levels in intestine liquids were lower than in gizzard liquids. Calcareous grit simulations maintained 2.5-34 times more Ca in solution than those that used siliceous grit. Dietary supplementation with calcareous grit may reduce Pb bioaccessibility of ingested Pb shot in birds by reducing gizzard acidity, by enhancing Pb precipitation (as Pb-carbonate), and by promoting higher dissolved Ca levels in the intestine, which may then compete with Pb for intestinal absorption.
Monica Martinez-Haro; Mark A Taggart; Andy J Green; Rafael Mateo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  43     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9480-6     Citation Subset:  IM    
Instituto de Investigaci?n en Recursos Cin?geticos, IREC (CSIC-UCLM-JCCM), 13071 Ciudad Real, Spain.
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MeSH Terms
Feeding Behavior
Gastrointestinal Tract / physiology*
Gizzard / metabolism*
Lead* / metabolism,  toxicity
Lead Poisoning / veterinary
Models, Biological*
Quality Control
Solutions / chemistry*
Reg. No./Substance:
0/Solutions; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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