Document Detail


Avecor Trillium oxygenator versus noncoated Monolyth oxygenator: a prospective randomized controlled study.
MedLine Citation:
PMID:  18598318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The surface coating of a synthetic surface is currently investigated to decrease the harmful effects of cardiopulmonary bypass (CPB). This study was designed to study the effects of the surface coating of a hollow fiber membrane oxygenator on coagulation, inflammation markers, and clinical outcomes. The biomaterials used to coat the membrane include heparin, polyethylene oxide chains (PEO), and sulfate/sulfonate groups. The coated membrane was compared to an uncoated oxygenator made of polypropylene. METHODS: Two hundred patients who were scheduled to undergo valve repair and/or replacement surgery with or without coronary surgery were enrolled in the study. The patients were randomized to undergo CPB with either the Avecor oxygenator with Trillium (Medtronic, Minneapolis, MN, USA), a biopassive surface, or the Monolyth (Sorin, Irvine, CA, USA) oxygenator without coating. The primary and secondary endpoints were the differences between these oxygenators in regard to patients' biochemistry, coagulation profiles, inflammatory mediators, and clinical outcomes, including blood loss and neurological events. RESULTS: There were no differences between the two groups in terms of biochemistry, coagulation profile, inflammatory mediator release, and blood loss. Five patients in the Avecor group showed clinical evidence of a stroke confirmed with computerized tomography (CT) scan imaging, and none in the noncoated oxygenator group. CONCLUSION: The oxygenator Avecor offers similar results in terms of inflammation and coagulation profiles and blood loss during valvular surgery compared to a standard uncoated control oxygenator. The rate of neurological events was unusually elevated in the former group of patients, with only speculative explanation at this point. Further studies are warranted to clarify this aspect.
Authors:
Frédéric Vanden Eynden; Michel Carrier; Sandra Ouellet; Philippe Demers; Jessica Forcillo; Louis P Perrault; Michel Pellerin; Denis Bouchard
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac surgery     Volume:  23     ISSN:  0886-0440     ISO Abbreviation:  J Card Surg     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-07-07     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908809     Medline TA:  J Card Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  288-93     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, Erasmus Hospital, Free University of Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Coagulation
Blood Loss, Surgical
Cardiopulmonary Bypass*
Coated Materials, Biocompatible
Female
Heart Valves / surgery
Heparin
Humans
Inflammation Mediators / blood
Length of Stay
Male
Middle Aged
Oxygenators, Membrane* / adverse effects
Polyethylene Glycols
Polypropylenes
Stroke / etiology
Sulfates
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Inflammation Mediators; 0/Polyethylene Glycols; 0/Polypropylenes; 0/Sulfates; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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