| Avastin Doesn't Blind People, People Blind People. | |
| | |
MedLine Citation:
|
PMID: 22264942 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: To review the appropriate preparation of bevacizumab for intravitreal injection by compounding pharmacies with specific recommendations designed to prevent microbial contamination. DESIGN: Perspective. METHODS: A review and discussion of compounding issues with supporting literature, clinical experience, illustrations, and expert opinion. RESULTS: Closer examination of the events surrounding the recent clusters of infectious endophthalmitis cases occurring after the intravitreal injection of bevacizumab suggest that the vision loss is not the result of the drug or the injection technique, but rather of the compounding procedures used to prepare the syringes containing the bevacizumab. Noncompliance with recognized standards and poor aseptic technique are the most likely causes of these outbreaks. The key to preventing these catastrophic occurrences depends on the implementation of and strict adherence to United States Pharmacopoeia Chapter 797 requirements. CONCLUSIONS: Recommendations arising from a root cause analysis of infectious endophthalmitis outbreaks should focus on the procedures used by pharmacies to compound bevacizumab. Microbial contamination of bevacizumab-containing syringes prepared from the same vial of drug can be avoided by using a single vial of bevacizumab for each eye or by following strict adherence to United States Pharmacopoeia Chapter 797 requirements when compounding a single vial of bevacizumab into multiple syringes. |
| | |
Authors:
|
Serafin Gonzalez; Philip J Rosenfeld; Michael W Stewart; Jennifer Brown; Steven P Murphy |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of ophthalmology Volume: 153 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
|
Languages: eng Pagination: 196-203.e1 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interaction of Merocyanine 540 with serum albumins: Photophysical and binding studies.
Next Document: An outbreak of streptococcus endophthalmitis after intravitreal injection of bevacizumab.