Document Detail

Avascular osteonecrosis after treatment of SARS: a 3-year longitudinal study.
MedLine Citation:
PMID:  19508438     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between avascular osteonecrosis (AVN) and corticosteroid treatment given to patients with severe acute respiratory syndrome (SARS). METHODS: Longitudinal study of 71 former SARS patients (mainly health care workers) who had been treated with corticosteroids, with an observation time of 36 months. Magnetic resonance images (MRI) and X-rays of hips, knees, shoulders, ankles and wrists were taken as part of the post-SARS follow-up assessments. RESULTS: Thirty-nine per cent developed AVN of the hips within 3-4 months after starting treatment. Two more cases of hip necrosis were seen after 1 year and another 11 cases of AVN were diagnosed after 3 years, one with hip necrosis and 10 with necrosis in other joints. In total, 58% of the cohort had developed AVN after 3 years of observation. The sole factor explaining AVN in the hip was the total dose of corticosteroids received. CONCLUSION: The use of corticosteroids in SARS has been debated; opinions conflict about whether the immediate benefits in terms of saving lives compensate for the adverse effects, including AVN.
Hui Lv; Sake J de Vlas; Wei Liu; Tian-Bao Wang; Zhao-Yang Cao; Chun-Peng Li; Wu-Chun Cao; Jan Hendrik Richardus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-05
Journal Detail:
Title:  Tropical medicine & international health : TM & IH     Volume:  14 Suppl 1     ISSN:  1365-3156     ISO Abbreviation:  Trop. Med. Int. Health     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-09     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610576     Medline TA:  Trop Med Int Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
Chinese People's Armed Forces (CPAF) Hospital of Beijing, P.R. China.
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MeSH Terms
Adrenal Cortex Hormones / administration & dosage,  adverse effects*
Immunoglobulin G / blood
Longitudinal Studies
Magnetic Resonance Imaging
Middle Aged
Multivariate Analysis
Osteonecrosis / chemically induced*,  diagnosis,  epidemiology
Prednisolone / administration & dosage,  adverse effects*
Severe Acute Respiratory Syndrome / drug therapy*
Young Adult
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Immunoglobulin G; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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