| Avascular villi, increased syncytial knots, and hypervascular villi are associated with pregnancies complicated by factor V Leiden mutation. | |
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MedLine Citation:
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PMID: 20121426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is controversy about whether pathologic abnormalities are associated with pregnancies complicated by factor V Leiden (FVL) mutation. The purpose of this study was to evaluate 105 placentas delivered to mothers heterozygous for FVL mutation to determine if there are pathologic changes suggestive of hypoxia or thrombosis, which correlate with mutation status. We examined placentas obtained as part of a prospective study of 5188 pregnancies analyzed for the presence of FVL mutation in either the mother or the infant. One hundred five placentas from mothers heterozygous for the mutation were compared with 225 controls matched for maternal age, race, and geographic site. Of the 330 pregnancies, 50 infants were FVL mutation heterozygotes. Maternal FVL heterozygote status was associated with more frequent increased numbers of syncytial knots (13% vs 4%); the difference remained significant after controlling for hypertension, preeclampsia, small-for-gestational-age infants, and delivery prior to 35 weeks of gestation (odds ratio 3.6, 95% confidence interval 1.5-8.7, P = 0.004). Maternal FVL heterozygotes had more hypervascular villi (10% vs 3%), with significance retained controlling for delivery route (odds ratio 3.4, 95% confidence ratio 1.2-9.4, P = 0.018). Placentas from infants heterozygous for FVL mutation had more avascular villi than controls (odds ratio 2.9, 95% confidence interval 1.5-5.6, P = 0.001). Fetal or maternal FVL heterozygosity was not associated with infarcts, small-for-gestational-age placentas, or fetal thrombotic vasculopathy. This analysis demonstrates that pathologic findings associated with placental hypoxia, specifically focal avascular villi, increased numbers of syncytial knots, and hypervascular villi, also correlate with FVL heterozygosity in infants or mothers. |
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Authors:
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Beverly Barton Rogers; Valerija Momirova; Donna Dizon-Townson; Katharine Wenstrom; Philip Samuels; Baha Sibai; Catherine Spong; Steve N Caritis; Yoram Sorokin; Menachem Miodovnik; Mary J O'Sullivan; Deborah Conway; Ronald J Wapner |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural Date: 2010-02-01 |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 13 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-02-15 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 341-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, Children's Medical Center, Dallas, TX, USA. beverly.rogers@childrens.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Factor V
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genetics* Female Heterozygote Humans Mutation* Placenta Diseases / genetics* Pregnancy Thrombophilia / complications, genetics |
| Grant Support | |
ID/Acronym/Agency:
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HD21410/HD/NICHD NIH HHS; HD21414/HD/NICHD NIH HHS; HD27860/HD/NICHD NIH HHS; HD27861/HD/NICHD NIH HHS; HD27869/HD/NICHD NIH HHS; HD27905/HD/NICHD NIH HHS; HD27915/HD/NICHD NIH HHS; HD27917/HD/NICHD NIH HHS; HD34116/HD/NICHD NIH HHS; HD34122/HD/NICHD NIH HHS; HD34136/HD/NICHD NIH HHS; HD34208/HD/NICHD NIH HHS; HD34210/HD/NICHD NIH HHS; HD36801/HD/NICHD NIH HHS; U01 HD036801-02/HD/NICHD NIH HHS; U10 HD021410-14/HD/NICHD NIH HHS; U10 HD021414-09S1/HD/NICHD NIH HHS; U10 HD027860-11/HD/NICHD NIH HHS; U10 HD027861-10/HD/NICHD NIH HHS; U10 HD027869-11/HD/NICHD NIH HHS; U10 HD027905-09/HD/NICHD NIH HHS; U10 HD027915-08/HD/NICHD NIH HHS; U10 HD027917-09/HD/NICHD NIH HHS; U10 HD034116-04/HD/NICHD NIH HHS; U10 HD034116-15/HD/NICHD NIH HHS; U10 HD034122-04/HD/NICHD NIH HHS; U10 HD034136-08/HD/NICHD NIH HHS; U10 HD034208-05/HD/NICHD NIH HHS; U10 HD034210-04/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/factor V Leiden; 9001-24-5/Factor V |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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