Document Detail


Avarol, a cytostatically active compound from the marine sponge Dysidea avara.
MedLine Citation:
PMID:  2858349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A main metabolic product of the sponge Dysidea avara was isolated and purified and subsequently identified as avarol by applying a series of analytical techniques, e.g. [13C]NMR, [1H]NMR and i.r. spectroscopy. This sesquiterpenoid hydroquinone was found to possess strong cytostatic activity. Using the L5178y mouse lymphoma cell system in vitro (roller tube assays) avarol reduced cell growth to 50% at a concentration of 0.9 microM. Avarol treated cells did not show "unbalanced growth". Avarol interfered with mitotic processes, preventing telophase formation. Incorporation studies with precursors for DNA, RNA, protein and glycoprotein syntheses revealed increased incorporation rates in response to avarol treatment. From these results and further autoradiographical experiments it is suggested that inhibition of cell growth is due to changes of the intracellular pools and/or alterations of the permeability properties of the cell membrane for the precursors. Avarol diacetate caused the same cytostatic effect as avarol.
Authors:
W E Müller; R K Zahn; M J Gasić; N Dogović; A Maidhof; C Becker; B Diehl-Seifert; E Eich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  80     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-05-17     Completed Date:  1985-05-17     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents*
Autoradiography
Cell Division / drug effects*
Cells, Cultured
DNA, Neoplasm / biosynthesis
Lymphoma / drug therapy
Mitosis / drug effects
Neoplasm Proteins / biosynthesis
Porifera / analysis*
RNA, Neoplasm / biosynthesis
Sesquiterpenes / pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/DNA, Neoplasm; 0/Neoplasm Proteins; 0/RNA, Neoplasm; 0/Sesquiterpenes; 55303-98-5/avarol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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