Document Detail

Avant garde fatty acid synthesis by trypanosomes.
MedLine Citation:
PMID:  16923380     Owner:  NLM     Status:  MEDLINE    
In this issue of Cell, Lee et al. (2006) report that the parasite Trypanosoma brucei synthesizes fatty acids in an unconventional way. T. brucei and two other trypanosomes use enzymes called elongases to synthesize myristate, a fourteen carbon (C14) fatty acid essential for pathogenesis. This is an unexpected finding as these enzymes were thought only to elongate already long (C16 or C18) acyl chains.
John E Cronan
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  126     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2006-10-31     Revised Date:  2010-08-09    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  641-3     Citation Subset:  IM    
Department of Microbiology, University of Illinois, Urbana, 61801, USA.
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MeSH Terms
Fatty Acids / biosynthesis*
Myristic Acid / metabolism*
Protozoan Proteins / genetics,  metabolism
Trypanosoma brucei brucei / genetics,  metabolism*,  pathogenicity
Grant Support
R01 AI015650-30/AI/NIAID NIH HHS
Reg. No./Substance:
0/Fatty Acids; 0/Protozoan Proteins; 544-63-8/Myristic Acid
Comment On:
Cell. 2006 Aug 25;126(4):691-9   [PMID:  16923389 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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