| Availability of phenindione-beta-cyclodextrin inclusion complex. | |
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MedLine Citation:
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PMID: 1409827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inclusion complexation was occurred between beta-cyclodextrin (beta-CD) and phenindione (1) in aqueous solution. The complex formation was proved by solubility, dissolution and permeation study. The inclusion complex was prepared and its physicochemical properties was studied. 1 was combined with beta-CD in 1:1 molar ratio. Using the solubility data, the value of apparent stability constant obtained of 1/beta-CD complex was 492.7. The dissolution rate of 1 was increased in presence of beta-CD. The permeability coefficients of 1 were 7.86 x 10(-3), 4.76 x 10(-3) and 5.0 x 10(-3), corresponding to pure drug, its physical mixture with beta-CD and the inclusion complex, respectively. The presence of human albumin generally decreased the permeability coefficient of the drug. The reduction (79.5%) was found to be nearly equal in case of either pure 1 or its complex with beta-CD. Administration of 1 or its inclusion complex with beta-CD to rabbits increase prothrombin times, the effect was more pronounced in the complex form of drug than free one. |
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Authors:
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S S Tous; A M el-Sayed; S A el-Harras; H W Jun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 47 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-11-04 Completed Date: 1992-11-04 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY |
Other Details:
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Languages: eng Pagination: 365-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Availability Chemistry, Pharmaceutical Cyclodextrins / pharmacokinetics* Humans Male Permeability Phenindione / pharmacokinetics*, pharmacology Prothrombin Time Rabbits Serum Albumin Solubility Spectrophotometry, Infrared X-Ray Diffraction beta-Cyclodextrins* |
| Chemical | |
Reg. No./Substance:
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0/Cyclodextrins; 0/Serum Albumin; 0/beta-Cyclodextrins; 7585-39-9/betadex; 83-12-5/Phenindione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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