| Availability of drug assay results and dosage advice improves antiepileptic care in a specialist neurology outpatient clinic. | |
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MedLine Citation:
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PMID: 3843216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of grand mal seizures, distribution of drug levels relative to the therapeutic range and the incidence of side effects were monitored before and after the provision of same-day preconsultation assay results (phenytoin and carbamazepine) to an epilepsy clinic. A total of 300 patients completed the study. The proportion of patients fitting fell from 23.3% at entry to 10% at review (P less than 0.01) while the incidence of side effects fell from 30.7% to 17.3% (P less than 0.01) and the proportion of phenytoin levels in the therapeutic range rose from 41% to 58% (P less than 0.01). Similar patterns were observed in 111 patients who entered the study during a control observation period. The provision of appropriate support services (assay results and dosage advice) to specialist epilepsy clinics allows improvement in the management of epilepsy. |
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Authors:
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L L Ioannides-Demos; A J McLean; J Wodak; N Tong; U Heinzow; M Horne; P M Harrison; B S Gilligan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental neurology Volume: 21 ISSN: 0196-6383 ISO Abbreviation: Clin Exp Neurol Publication Date: 1985 |
Date Detail:
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Created Date: 1987-06-23 Completed Date: 1987-06-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7909724 Medline TA: Clin Exp Neurol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 171-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Carbamazepine / blood*, therapeutic use Dose-Response Relationship, Drug Epilepsy / drug therapy* Humans Outpatient Clinics, Hospital Pharmacy Service, Hospital* Phenytoin / blood*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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298-46-4/Carbamazepine; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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