Document Detail


Availability of drug assay results and dosage advice improves antiepileptic care in a specialist neurology outpatient clinic.
MedLine Citation:
PMID:  3843216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of grand mal seizures, distribution of drug levels relative to the therapeutic range and the incidence of side effects were monitored before and after the provision of same-day preconsultation assay results (phenytoin and carbamazepine) to an epilepsy clinic. A total of 300 patients completed the study. The proportion of patients fitting fell from 23.3% at entry to 10% at review (P less than 0.01) while the incidence of side effects fell from 30.7% to 17.3% (P less than 0.01) and the proportion of phenytoin levels in the therapeutic range rose from 41% to 58% (P less than 0.01). Similar patterns were observed in 111 patients who entered the study during a control observation period. The provision of appropriate support services (assay results and dosage advice) to specialist epilepsy clinics allows improvement in the management of epilepsy.
Authors:
L L Ioannides-Demos; A J McLean; J Wodak; N Tong; U Heinzow; M Horne; P M Harrison; B S Gilligan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental neurology     Volume:  21     ISSN:  0196-6383     ISO Abbreviation:  Clin Exp Neurol     Publication Date:  1985  
Date Detail:
Created Date:  1987-06-23     Completed Date:  1987-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909724     Medline TA:  Clin Exp Neurol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Carbamazepine / blood*,  therapeutic use
Dose-Response Relationship, Drug
Epilepsy / drug therapy*
Humans
Outpatient Clinics, Hospital
Pharmacy Service, Hospital*
Phenytoin / blood*,  therapeutic use
Chemical
Reg. No./Substance:
298-46-4/Carbamazepine; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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