Document Detail

Availability of drug assay results and dosage advice improves antiepileptic care in a specialist neurology outpatient clinic.
MedLine Citation:
PMID:  3843216     Owner:  NLM     Status:  MEDLINE    
The incidence of grand mal seizures, distribution of drug levels relative to the therapeutic range and the incidence of side effects were monitored before and after the provision of same-day preconsultation assay results (phenytoin and carbamazepine) to an epilepsy clinic. A total of 300 patients completed the study. The proportion of patients fitting fell from 23.3% at entry to 10% at review (P less than 0.01) while the incidence of side effects fell from 30.7% to 17.3% (P less than 0.01) and the proportion of phenytoin levels in the therapeutic range rose from 41% to 58% (P less than 0.01). Similar patterns were observed in 111 patients who entered the study during a control observation period. The provision of appropriate support services (assay results and dosage advice) to specialist epilepsy clinics allows improvement in the management of epilepsy.
L L Ioannides-Demos; A J McLean; J Wodak; N Tong; U Heinzow; M Horne; P M Harrison; B S Gilligan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental neurology     Volume:  21     ISSN:  0196-6383     ISO Abbreviation:  Clin Exp Neurol     Publication Date:  1985  
Date Detail:
Created Date:  1987-06-23     Completed Date:  1987-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909724     Medline TA:  Clin Exp Neurol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
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MeSH Terms
Carbamazepine / blood*,  therapeutic use
Dose-Response Relationship, Drug
Epilepsy / drug therapy*
Outpatient Clinics, Hospital
Pharmacy Service, Hospital*
Phenytoin / blood*,  therapeutic use
Reg. No./Substance:
298-46-4/Carbamazepine; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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