Document Detail

Autoxidation of polyunsaturated esters in water: chemical structure and biological activity of the products.
MedLine Citation:
PMID:  4860576     Owner:  NLM     Status:  MEDLINE    
When polyunsaturated esters or fatty acids are dispersed for long periods in water in the presence of air, water-soluble substances are formed in great variety. Because these short-chain products are constantly eluted by the aqueous phase and are consequently not available for further reaction in the oil phase, many intermediates of classical autoxidation can be isolated and identified. The identification of several of these compounds is described. Some of the peroxidic and nonperoxidic autoxidation products show biochemical activity-in particular, inhibition of glycolysis and of respiration during incubation with tumor cells in vitro. Minimal inhibitory concentrations of pure, isolated products have been determined for Ehrlich ascites tumor cells. Synthetic short-chain (C(4)-C(10)) hydroxylated alpha,-unsaturated aldehydes have been shown to have this action and also to cause morphological changes in these cells which quickly lead to their death. Normal cells are not affected. Possible therapeutic use of these compounds in the treatment of malignant neoplasms is discussed.
E Schauenstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of lipid research     Volume:  8     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1967 Sep 
Date Detail:
Created Date:  1967-12-14     Completed Date:  1967-12-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  417-28     Citation Subset:  IM    
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MeSH Terms
Aldehydes / pharmacology
Antimetabolites / pharmacology
Chemical Phenomena
Culture Techniques
Fats, Unsaturated*
Peroxides / analysis,  pharmacology
Reg. No./Substance:
0/Aldehydes; 0/Antimetabolites; 0/Fats, Unsaturated; 0/Peroxides; 0/Solutions

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