| Autoxidation of polyunsaturated esters in water: chemical structure and biological activity of the products. | |
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MedLine Citation:
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PMID: 4860576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When polyunsaturated esters or fatty acids are dispersed for long periods in water in the presence of air, water-soluble substances are formed in great variety. Because these short-chain products are constantly eluted by the aqueous phase and are consequently not available for further reaction in the oil phase, many intermediates of classical autoxidation can be isolated and identified. The identification of several of these compounds is described. Some of the peroxidic and nonperoxidic autoxidation products show biochemical activity-in particular, inhibition of glycolysis and of respiration during incubation with tumor cells in vitro. Minimal inhibitory concentrations of pure, isolated products have been determined for Ehrlich ascites tumor cells. Synthetic short-chain (C(4)-C(10)) hydroxylated alpha,-unsaturated aldehydes have been shown to have this action and also to cause morphological changes in these cells which quickly lead to their death. Normal cells are not affected. Possible therapeutic use of these compounds in the treatment of malignant neoplasms is discussed. |
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Authors:
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E Schauenstein |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of lipid research Volume: 8 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1967 Sep |
Date Detail:
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Created Date: 1967-12-14 Completed Date: 1967-12-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 417-28 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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pharmacology Antimetabolites / pharmacology Chemical Phenomena Chemistry Culture Techniques Fats, Unsaturated* Oxidation-Reduction Peroxides / analysis, pharmacology Solutions |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Antimetabolites; 0/Fats, Unsaturated; 0/Peroxides; 0/Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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