Document Detail

Autotransfusion after open heart surgery: the oxygen delivery capacity of shed mediastinal blood is maintained.
MedLine Citation:
PMID:  7484029     Owner:  NLM     Status:  MEDLINE    
Autotransfusion of mediastinal shed blood after open heart surgery has become a common and accepted procedure in reducing the need for homologous transfusion during the last 15 years. The objectives of the present study were to investigate the oxygen delivery capacity of autotransfused shed mediastinal blood, compared to patient-blood, during cardiopulmonary bypass and in the postoperative period. Ten consecutive patients undergoing elective cardiac surgery were studied. Mediastinal shed blood was collected in the cardiotomy reservoir and retransfused during the first 18 postoperative hours. The oxygen delivery capacity of the blood to the tissues was calculated by use of the oxygen status algorithm (OSA 2.0) programme and measurement of the 2,3-diphosphoglycerate (2,3-DPG) concentration. Autotransfusion volume ranged from 450-1530 ml per patient (median 824 ml). Shed blood had a mean haemoglobin level of 8.8 g/dl and 7.4 g/dl at 1 h and 6 h of autotransfusion, respectively. There were no significant changes of 2,3-DPG concentration in the patient-blood during cardiopulmonary bypass or after autotransfusion compared to preoperative values. P50 for oxygen (3.6 and 3.6 kPa) and 2,3-DPG concentrations (5.3 and 5.1 mikromol/ml erythrocyte) in shed mediastinal blood (1h and 6h postoperatively) were not significantly different compared to patient-blood. The results demonstrate that the oxygen delivery capacity of shed mediastinal blood is maintained and that the oxygen affinity of patient-blood is not influenced by autotransfusion.
H Schmidt; U Kongsgaard; J Kofstad; O Geiran; H E Refsum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  39     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-04     Completed Date:  1995-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  754-8     Citation Subset:  IM    
Department of Anaesthesia, Rikshospitalet, Oslo, Norway.
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MeSH Terms
Blood Loss, Surgical
Blood Transfusion, Autologous*
Cardiopulmonary Bypass
Coronary Artery Bypass*
Diphosphoglyceric Acids / blood
Hemoglobins / analysis
Mediastinum / blood supply
Middle Aged
Oxygen / blood*
Postoperative Care
Postoperative Period
Reg. No./Substance:
0/Diphosphoglyceric Acids; 0/Hemoglobins; 138-81-8/2,3-Diphosphoglycerate; 7782-44-7/Oxygen

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