Document Detail


Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians.
MedLine Citation:
PMID:  9497255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An autosomal genomic scan to search for linkage to obesity and energy metabolism was completed in Pima Indians, a population prone to obesity. Obesity was assessed by percent body fat (by hydrodensitometry) and fat distribution (the ratio of waist circumference to thigh circumference). Energy metabolism was measured in a respiratory chamber as 24-h metabolic rate, sleeping metabolic rate, and 24-h respiratory quotient (24RQ), an indicator of the ratio of carbohydrate oxidation to fat oxidation. Five hundred sixteen microsatellite markers with a median spacing of 6.4 cM were analyzed, in 362 siblings who had measurements of body composition and in 220 siblings who had measurements of energy metabolism. These comprised 451 sib pairs in 127 nuclear families, for linkage analysis to obesity, and 236 sib pairs in 82 nuclear families, for linkage analysis to energy metabolism. Pointwise and multipoint methods for regression of sib-pair differences in identity by descent, as well as a sibling-based variance-components method, were used to detect linkage. LOD scores >=2 were found at 11q21-q22, for percent body fat (LOD=2.1; P=.001), at 11q23-q24, for 24-h energy expenditure (LOD=2.0; P=.001), and at 1p31-p21 (LOD=2.0) and 20q11.2 (LOD=3.0; P=.0001), for 24RQ, by pointwise and multipoint analyses. With the variance-components method, the highest LOD score (LOD=2.3 P=.0006) was found at 18q21, for percent body fat, and at 1p31-p21 (LOD=2.8; P=.0003), for 24RQ. Possible candidate genes include LEPR (leptin receptor), at 1p31, and ASIP (agouti-signaling protein), at 20q11.2.
Authors:
R A Norman; P A Tataranni; R Pratley; D B Thompson; R L Hanson; M Prochazka; L Baier; M G Ehm; H Sakul; T Foroud; W T Garvey; D Burns; W C Knowler; P H Bennett; C Bogardus; E Ravussin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  62     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-23     Completed Date:  1998-04-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  659-68     Citation Subset:  IM    
Affiliation:
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016-5319, USA.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping*
Energy Metabolism / genetics*
Humans
Indians, North American*
Linkage (Genetics)*
Lod Score
Obesity / genetics*
Grant Support
ID/Acronym/Agency:
1 P41 RR03655/RR/NCRR NIH HHS; DK-47461/DK/NIDDK NIH HHS
Comments/Corrections

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