Document Detail


Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension.
MedLine Citation:
PMID:  11884284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coronary artery disease (CAD) is the leading cause of mortality in the developed world. Although several CAD risk factors, including measures of lipid metabolism, obesity, and blood pressure, have a genetic basis, many genes for CAD susceptibility have yet to be identified. Coronary atherosclerosis is the major cause of CAD, but many with coronary atherosclerosis lack symptoms. Thus, a major limitation of using symptomatic CAD endpoints (eg, sudden coronary death, myocardial infarction) as a study outcome is substantial disease misclassification. Coronary artery calcification (CAC) is part of the atherosclerotic process and is an independent predictor of CAD endpoints. In the present study, CAC was noninvasively quantified by electron beam computed tomography. We performed genome-wide multipoint mode-of-inheritance-free linkage analysis on affected sib pairs, defined as being > or = the 70th sex- and age-specific percentile for CAC quantity, in a sample of 29 families enriched for hypertension. Almost 95% of participants were asymptomatic for CAD. Our LOD score (log10 odds in favor of linkage) results provide evidence that chromosomal regions 6p21.3 (maximum LOD score=2.22, P=0.00070) and 10q21.3 (maximum LOD score=3.24, P=0.000057) may harbor genes associated with subclinical coronary atherosclerosis.
Authors:
Leslie A Lange; Ethan M Lange; Lawrence F Bielak; Carl D Langefeld; Sharon L Kardia; Patrick Royston; Stephen T Turner; Patrick F Sheedy; Eric Boerwinkle; Patricia A Peyser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  22     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-08     Completed Date:  2002-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-23     Citation Subset:  IM    
Affiliation:
Sections on Epidemiology and Biostatistics, Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calcinosis / genetics*,  radiography
Chromosome Mapping
Coronary Artery Disease / genetics*,  radiography
Family Health
Female
Genetic Predisposition to Disease*
Genome, Human
Humans
Hypertension / genetics*
Linkage (Genetics)
Male
Middle Aged
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
M01 RR00585/RR/NCRR NIH HHS; R01 HL46292/HL/NHLBI NIH HHS; U01 HL054457/HL/NHLBI NIH HHS; U01 HL054464/HL/NHLBI NIH HHS; U01 HL054481/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):359-60   [PMID:  11884274 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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