Document Detail


Autoregulation of renal blood flow and pressure-dependent renin release in autosomal dominant polycystic kidney disease of rats.
MedLine Citation:
PMID:  9044329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Han:SPRD (PKD) rat is a new animal model of autosomal dominant polycystic kidney disease (ADPKD) which resembles many clinical and pathoanatomical features of human ADPKD. The aim of the present study was to analyse age-dependent changes in renal haemodynamics and renal renin secretion which could be of pathophysiological importance in the course of the disease. We investigated glomerular filtration rate (GFR), renal blood flow (RBF), renal vascular resistance (RVR), plasma renin activity (PRA), the autoregulatory behaviour of RBF and the pressure-dependent plasma renin activity in conscious PKD rats compared with age-matched controls. Experiments were performed in conscious chronically instrumented PKD rats (age: 3 and 9 months) and their age-matched genetic controls. GFR in 3-(0.52 +/- 0.07 ml/min/100 g; n = 9) and 9-month-old (0.42 +/- 0.03 ml/min/100 g; n = 21) PKD rats were significantly lower (P < 0.05) than 3- (0.92 +/- 0.07 ml/min/100 g; n = 17) and 9-month-old (0.67 +/- 0.05 ml/min/100 g; n = 17) controls. Nine-month-old PKD revealed a significant (P < 0.005) resetting of the breakpoint of RBF autoregulation towards lower pressures (85.5 +/- 4.4 mmHg; n = 10) than either age-matched controls (102.8 +/- 2.5 mmHg; n = 11) or young PKD (107.5 +/- 4.4 mmHg; n = 6). The basal plasma renin activity was significantly (P < 0.05) lower in 3-month-old PKD than in old PKD and age-matched controls. A significant shift of threshold pressure for pressure-dependent renin release to lower pressures was observed in PKD rats. The observed improvement of autoregulatory reserve, at least in the low pressure range, could be of pathophysiological importance in delaying the progression of chronic renal failure in ADPKD. The suppression of the renin angiotensin system in young PKD could explain the fact that we did not observe hypertension in PKD rats, which is a major difference between this animal model and human ADPKD.
Authors:
C Braun; C Lüdicke; W Rebsch; N Gretz; F J van der Woude; P Rohmeiss
Related Documents :
6995929 - Increase in plasma renin activity, water intake and blood pressure following applicatio...
8021469 - Response to the captopril test is dependent on baseline renin profile.
8931839 - Inhibition of erythrocyte na,k-atpase activity during anticipatory hypoventilation in m...
21685669 - A differential pumping system to deliver windowless vuv photons at atmospheric pressure.
1145199 - Reciprocation of renin dependency with sodium volume dependency in renal hypertension.
19010879 - Does the renin-angiotensin system participate in regulation of human vasculogenesis and...
25287269 - Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage.
2750909 - Portal venous pressure and portasystemic shunting in experimental portal hypertension.
24666379 - Comparisons of ultrafine and fine particles in their associations with biomarkers refle...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  11 Suppl 6     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1996  
Date Detail:
Created Date:  1997-05-13     Completed Date:  1997-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  52-7     Citation Subset:  IM    
Affiliation:
V. Medical Department, University of Heidelberg, Klinikum, Mannheim, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Blood Pressure / physiology*
Homeostasis*
Male
Polycystic Kidney, Autosomal Dominant / blood,  physiopathology,  veterinary*
Rats / metabolism
Rats, Mutant Strains
Renal Circulation*
Renin / blood*
Rodent Diseases / blood*,  physiopathology*
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rat models of autosomal dominant polycystic kidney disease.
Next Document:  In vitro formation of cysts derived from a rat model of autosomal dominant polycystic kidney disease...