| Autoreactive B cells and epigenetics. | |
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MedLine Citation:
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PMID: 19644775 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Autoreactive B cells are central in the pathogenesis of autoimmune diseases (AID) not only by producing autoantibodies but also by secreting cytokines and by presenting autoantigens. Changes in DNA methylation, histone modifications, and miRNA expression, the hallmarks of epigenetic failure, characterize B cells isolated from patients with AID, highlighting the contribution of epigenetic processes to autoreactivity. Additional evidence of epigenetic involvement in the development of B cell autoreactivity comes from in vivo and in vitro studies using DNA demethylating agents as accelerating factors or histone deacetylase inhibitors as repressing factors. As a result, a better understanding of the altered epigenetic processes in AID and in particular in B cells opens perspectives for the development of new therapeutics. |
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Authors:
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Yves Renaudineau; Soizic Garaud; Christelle Le Dantec; Ruby Alonso-Ramirez; Capucine Daridon; Pierre Youinou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical reviews in allergy & immunology Volume: 39 ISSN: 1559-0267 ISO Abbreviation: Clin Rev Allergy Immunol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-06-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504368 Medline TA: Clin Rev Allergy Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 85-94 Citation Subset: IM |
Affiliation:
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EA2216 Immunology and Pathology, IFR 148 ScInBioS, Universit? de Brest, Universit? Europ?enne de Bretagne, Brest, France. yves.renaudineau@univ-brest.fr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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