| Autoradiographic study of type II-cell hyperplasia in lungs of mice chronicall exposed to urethane. | |
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MedLine Citation:
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PMID: 975209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperplasia of pulmonary alveolar epithelium was induced by exposure of adult mice to 0-1% urethane in drinking water, and their lungs were analysed using combined autoradiographic and morphometric methods. The response of pulmonary epithelium showed three phases: an initial one of 3 weeks in which the number of type II cells was consistently low and, after a transient decrease in 3H-thymidine labeling index, the latter steadily increased. Degenerating or dead type II cells were found, consequently this period was considered one in which cell death was disproportionately increased over cell production. Between the 3rd and 6th weeks the number of type II cells doubled, and thereafter increased at a slower rate. The 3H-thymidine labeling index reached its peak at 6 weeks. The third phase was marked by a decline in labeling index which returned to near-normal levels by the 16th week. The number of type II cells declined slowly after the 10th week and was still elevated at the end of the observation period. Tumors consisting of type II cells continued to arise even during the period of declining labeling index. The dissociation between the proliferative response which was reversible, and the neoplastic response which was not, supports the assumption that the major part of the observed population growth or hyperplasia induced by urethane was a form of regeneration repair secondary to cell death and may be unrelated to tumor growth. |
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Authors:
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S L Kauffman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell and tissue kinetics Volume: 9 ISSN: 0008-8730 ISO Abbreviation: Cell Tissue Kinet Publication Date: 1976 Sep |
Date Detail:
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Created Date: 1976-12-23 Completed Date: 1976-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0174107 Medline TA: Cell Tissue Kinet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 489-97 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division Cell Survival Epithelial Cells Epithelium / pathology Female Hyperplasia / chemically induced Kinetics Mice Pulmonary Alveoli / pathology* Urethane / adverse effects* |
| Chemical | |
Reg. No./Substance:
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51-79-6/Urethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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