Document Detail

Autoradiographic localisation of ascorbic acid-dependent binding sites for [125I]iodocyanopindolol in guinea-pig trachea.
MedLine Citation:
PMID:  3720838     Owner:  NLM     Status:  MEDLINE    
Light microscopic autoradiography showed that the supposedly beta-adrenoceptor-selective radioligand [125I]iodocyanopindolol (I-CYP) bound to sites in both the guinea-pig tracheal epithelium and smooth muscle that were sensitive to propranolol and isoprenaline. Low levels of binding were associated with sub-epithelial mucosal cells. Ascorbic acid caused a concentration-related increase in total I-CYP binding which was predominantly associated with the sub-epithelial mucosa, was not inhibited by propranolol, and was thus not associated with beta-adrenoceptors.
R G Goldie; D Spina; P J Rigby; J W Paterson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  124     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-15     Completed Date:  1986-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  179-82     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / metabolism*
Binding Sites
Bronchi / metabolism
Guinea Pigs
Muscle, Smooth / metabolism*
Pindolol / analogs & derivatives*,  metabolism
Radioligand Assay
Trachea / metabolism
Reg. No./Substance:
13523-86-9/Pindolol; 50-81-7/Ascorbic Acid; 83498-72-0/Iodocyanopindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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