Document Detail

Autopsy case of sudden maternal death from thrombotic thrombocytopenic purpura.
MedLine Citation:
PMID:  22765161     Owner:  NLM     Status:  MEDLINE    
A 31-year-old pregnant woman was transferred to the emergency room at 27 weeks of gestation. She had one-day history of fever and upper abdominal pain. Soon after admission, she underwent cardiopulmonary arrest. Autopsy was performed and multiple microthrombi were seen within the small-caliber vessels of many organs, but not in the lungs. Immunohistochemical staining revealed that the thrombi were rich in von Willebrand factor. We also obtained results which showed severely deficient plasma a disintegrin-like and metalloprotease with thrombospondin motifs (ADAMTS) 13 activity and positive ADAMTS13 inhibitor, confirming a diagnosis of thrombotic thrombocytopenic purpura. As far as we know, in Japan, this is the first autopsy report of sudden maternal death from thrombotic thrombocytopenic purpura. We expect that the routine laboratory application of ADAMTS13 assays for unknown thrombocytopenic patients during pregnancy may help in differential diagnosis at an earlier stage of the disease and facilitate tailor-made therapeutic intervention.
Takuma Yamamoto; Yoshihiro Fujimura; Yuko Emoto; Yukiko Kuriu; Morio Iino; Ryoji Matoba
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-06
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  39     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-12-09     Revised Date:  2014-03-11    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  351-4     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.
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MeSH Terms
Death, Sudden / pathology*
Fatal Outcome
Maternal Death*
Purpura, Thrombotic Thrombocytopenic / pathology*
Comment In:
J Obstet Gynaecol Res. 2014 Feb;40(2):637   [PMID:  24245646 ]

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