| Autophagy for tissue homeostasis and neuroprotection. | |
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MedLine Citation:
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PMID: 21030235 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Although autophagy has frequently been viewed as a cell death mechanism in the mammalian system, it is now considered as indispensable for the homeostasis of cells, tissues, and organisms. Basal or stress-induced autophagy plays essential and diverse roles in a variety of tissues, due to its cytoprotective properties. In this review, we briefly discuss the different homeostatic functions of autophagy that have been finely dissected in mammals through the generation and characterization of animal models with tissue-specific autophagic alterations. In addition, and given the importance of constitutive autophagy in neuronal tissues, we describe in more detail the specific roles of autophagy in the central nervous system (CNS). Finally, we discuss the contribution of autophagy malfunctions to the development of several common neurological disorders and the potential benefits of pharmacologically induced autophagy for the avoidance of neurodegeneration. |
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Authors:
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Guillermo Mariño; Frank Madeo; Guido Kroemer |
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Publication Detail:
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Type: Journal Article Date: 2010-10-26 |
Journal Detail:
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Title: Current opinion in cell biology Volume: 23 ISSN: 1879-0410 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 198-206 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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INSERM, U848, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France; Université Paris Sud, Paris 11, F-94805 Villejuif, France. |
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