Document Detail


Autophagy: a target for retinoic acids.
MedLine Citation:
PMID:  20953149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autophagy is an intracellular catabolic process that responds with great sensitivity to nutrient availability, implying that certain macro- or micro-nutrients are involved. We found that retinoic acid promotes autophagosome maturation through a pathway independent from the classic nuclear retinoid receptors. Retinoic acid redistributes the cation-independent mannose-6-phosphate receptor from the trans-Golgi region to maturing autophagosomal structures inducing their acidification. Manipulation of the autophagic activity by retinoids could have enormous health implications, since they are essential dietary components and frequently used pharmaceuticals.
Authors:
Yogendra Rajawat; Zoe Hilioti; Ioannis Bossis
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Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Autophagy     Volume:  6     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-03-02     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1224-6     Citation Subset:  IM    
Affiliation:
Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Autophagy / drug effects*
Hela Cells
Humans
Models, Biological
Phagosomes / drug effects,  metabolism
Receptor, IGF Type 2 / metabolism
Receptors, Retinoic Acid / metabolism
Recombinant Fusion Proteins / metabolism
Sirolimus / pharmacology
Tretinoin / pharmacology*
trans-Golgi Network / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Receptor, IGF Type 2; 0/Receptors, Retinoic Acid; 0/Recombinant Fusion Proteins; 302-79-4/Tretinoin; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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