| Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise. | |
| | |
MedLine Citation:
|
PMID: 22194006 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The purpose of this study was to evaluate whether ultra endurance exercise changes the mRNA levels of the autophagy-related and autophagy-regulatory genes. Eight men (44 ± 1 years, range: 38-50 years) took part in a 200-km running race. The average running time was 28 h 03 min ± 2 h 01 min (range: 22 h 15 min-35 h 04 min). A muscle sample was taken from the vastus lateralis 2 weeks prior to the race and 3 h after arrival. Gene expression was assessed by RT-qPCR. Transcript levels of autophagy-related genes were increased by 49% for ATG4b (P = 0.025), 57% for ATG12 (P = 0.013), 286% for Gabarapl1 (P = 0.008) and 103% for LC3b (P = 0.011). The lysosomal enzyme cathepsin L mRNA was upregulated by 123% (P = 0.003). Similarly, transcript levels of the autophagy-regulatory genes BNIP3 and BNIP3l were both increased by 113% (P = 0.031 and P = 0.007, respectively). Since upregulation of these genes has been related with an increased autophagic flux in various models, our results strongly suggest that autophagy is activated in response to ultra endurance exercise. |
| | |
Authors:
|
Cécile Jamart; Nicolas Benoit; Jean-Marc Raymackers; Hyo Jeong Kim; Chang Keun Kim; Marc Francaux |
Related Documents
:
|
20950486 - Identification of expression qtl (eqtl) of genes expressed in porcine m. longissimus do... 17218816 - The early-life origins of asthma. 16246256 - Inherited defects of coagulation factor v: the thrombotic side. 20419766 - Epidemiologic and genetic aspects of spina bifida and other neural tube defects. 22688726 - Mining the human gut microbiome for novel stress resistance genes. 21183046 - Differential expression of genes in adipose tissue of first-lactation dairy cattle. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
|
Title: European journal of applied physiology Volume: - ISSN: 1439-6327 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Institute of Neuroscience, Research Group in Muscle and Exercise Physiology, Université catholique de Louvain, Place Pierre de Coubertin 1, 1348, Louvain-la-Neuve, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of high-intensity interval training on pulmonary function.
Next Document: Evidence for repetitive load in the trapezius muscle during a tapping task.