| Autophagy, reactive oxygen species and the fate of mammalian cells. | |
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MedLine Citation:
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PMID: 20964552 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract The paper reviews the rapidly expanding pool of information on cellular and molecular mechanisms of autophagy, including autophagy types, macroautophagy induction, formation of autophagosomes and cross-talk between autophagy and apoptosis. Special attention is given to generation of reactive oxygen species (ROS) in various cellular compartments of cells under stress conditions inducing autophagy. The roles of hydrogen peroxide and superoxide in autophagy are analysed based on the recent experimental work. The relation between ROS and life span prolongation is briefly discussed, with the final conclusion that the paradox of dual role of ROS in life and death may be solved to a considerable extent due to research on autophagy. |
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Authors:
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Irena Szumiel |
Publication Detail:
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Type: Journal Article Date: 2010-10-22 |
Journal Detail:
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Title: Free radical research Volume: 45 ISSN: 1029-2470 ISO Abbreviation: Free Radic. Res. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 253-65 Citation Subset: IM |
Affiliation:
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Center of Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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